Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels
Identifieur interne : 000389 ( Main/Exploration ); précédent : 000388; suivant : 000390Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels
Auteurs : Wei Zhang [République populaire de Chine] ; Xiao-Shuang Zheng [République populaire de Chine] ; Bernard Agwanda [Kenya] ; Sheila Ommeh [Kenya] ; Kai Zhao [République populaire de Chine] ; Jacqueline Lichoti [Kenya] ; Ning Wang [République populaire de Chine] ; Jing Chen [République populaire de Chine] ; Bei Li [République populaire de Chine] ; Xing-Lou Yang [République populaire de Chine] ; Shailendra Mani [Singapour] ; Kisa-Juma Ngeiywa [Kenya] ; Yan Zhu [République populaire de Chine] ; Ben Hu [République populaire de Chine] ; Samson Omondi Onyuok [République populaire de Chine] ; Bing Yan [République populaire de Chine] ; Danielle E. Anderson [Singapour] ; Lin-Fa Wang [Singapour] ; Peng Zhou [République populaire de Chine] ; Zheng-Li Shi [République populaire de Chine]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Chameaux (sang), Chameaux (virologie), Chiroptera (virologie), Coronavirus (génétique), Coronavirus (immunologie), Coronavirus (isolement et purification), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Glycoprotéine de spicule des coronavirus (immunologie), Infections à coronavirus (médecine vétérinaire), Infections à coronavirus (sang), Infections à coronavirus (virologie), Kenya, Protéines nucléocapside (immunologie), Recombinaison génétique.
- MESH :
- génétique : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient, Glycoprotéine de spicule des coronavirus, Protéines nucléocapside.
- isolement et purification : Coronavirus, Coronavirus du syndrome respiratoire du Moyen-Orient.
- médecine vétérinaire : Infections à coronavirus.
- sang : Anticorps antiviraux, Chameaux, Infections à coronavirus.
- virologie : Chameaux, Chiroptera, Infections à coronavirus.
- Animaux, Kenya, Recombinaison génétique.
- Wicri :
- geographic : Kenya.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Camelus (blood), Camelus (virology), Chiroptera (virology), Coronavirus (genetics), Coronavirus (immunology), Coronavirus (isolation & purification), Coronavirus Infections (blood), Coronavirus Infections (veterinary), Coronavirus Infections (virology), Kenya, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Nucleocapsid Proteins (immunology), Recombination, Genetic, Spike Glycoprotein, Coronavirus (immunology).
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Nucleocapsid Proteins, Spike Glycoprotein, Coronavirus.
- geographic : Kenya.
- blood : Camelus, Coronavirus Infections.
- genetics : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- immunology : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Coronavirus, Middle East Respiratory Syndrome Coronavirus.
- veterinary : Coronavirus Infections.
- virology : Camelus, Chiroptera, Coronavirus Infections.
- Animals, Recombination, Genetic.
Abstract
Dromedary camels are important reservoir hosts of various coronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV) that cause human infections. CoV genomes regularly undergo recombination during infection as observed in bat SARS-related CoVs. Here we report for the first time that only a small proportion of MERS-CoV receptor-binding domain positive (RBD) of spike protein positive camel sera in Kenya were also seropositive to MERS-CoV nucleocapsid (NP). In contrast, many of them contain antibodies against bat HKU8-related (HKU8r)-CoVs. Among 584 camel samples that were positive against MERS-CoV RBD, we found only 0.48 (8.22%) samples were also positive for NP. Furthermore, we found bat HKU8r-CoV NP antibody in 73 (12.5%) of the MERS-CoV RBD positive and NP negative samples, yet found only 3 (0.43%) of the HKU8r-CoV S1 antibody in the same samples. These findings may indicate co-infection with MERS-CoV and a HKU8r-CoV in camels. It may also raise the possibility of the circulation of a recombinant coronavirus virus with the spike of MERS-CoV and the NP of a HKU8r-CoV in Kenya. We failed to find molecular evidence of an HKU8r-CoV or a putative recombinant virus. Our findings should alert other investigators to look for molecular evidence of HKU8r-CoV or recombinants.
Url:
DOI: 10.1080/22221751.2019.1679610
PubMed: 31645223
PubMed Central: 6818114
Affiliations:
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country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Onyuok, Samson Omondi" sort="Onyuok, Samson Omondi" uniqKey="Onyuok S" first="Samson Omondi" last="Onyuok">Samson Omondi Onyuok</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of 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of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31645223</idno><idno type="pmc">6818114</idno><idno 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China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Xiao Shuang" sort="Zheng, Xiao Shuang" uniqKey="Zheng X" first="Xiao-Shuang" last="Zheng">Xiao-Shuang Zheng</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF2"><institution>University of Chinese Academy of Sciences</institution>, Beijing,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Agwanda, Bernard" sort="Agwanda, Bernard" uniqKey="Agwanda B" first="Bernard" last="Agwanda">Bernard Agwanda</name><affiliation wicri:level="1"><nlm:aff id="AF3"><institution>Department of Zoology, National Museums of Kenya</institution>, Nairobi,<country>Kenya</country></nlm:aff><country xml:lang="fr">Kenya</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ommeh, Sheila" sort="Ommeh, Sheila" uniqKey="Ommeh S" first="Sheila" last="Ommeh">Sheila Ommeh</name><affiliation wicri:level="1"><nlm:aff id="AF4"><institution>Institute for Biotechnology Research, Jomo Kenyatta University of Agriculture and Technology</institution>, Nairobi,<country>Kenya</country></nlm:aff><country xml:lang="fr">Kenya</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Kai" sort="Zhao, Kai" uniqKey="Zhao K" first="Kai" last="Zhao">Kai Zhao</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF2"><institution>University of Chinese Academy of Sciences</institution>, Beijing,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lichoti, Jacqueline" sort="Lichoti, Jacqueline" uniqKey="Lichoti J" first="Jacqueline" last="Lichoti">Jacqueline Lichoti</name><affiliation wicri:level="1"><nlm:aff id="AF5"><institution>Directorate of Veterinary Services, State Department of Livestock, Ministry of Agriculture</institution>, Livestock and Fisheries,<country>Kenya</country></nlm:aff><country xml:lang="fr">Kenya</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Ning" sort="Wang, Ning" uniqKey="Wang N" first="Ning" last="Wang">Ning Wang</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Jing" sort="Chen, Jing" uniqKey="Chen J" first="Jing" last="Chen">Jing Chen</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF2"><institution>University of Chinese Academy of Sciences</institution>, Beijing,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Bei" sort="Li, Bei" uniqKey="Li B" first="Bei" last="Li">Bei Li</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Xing Lou" sort="Yang, Xing Lou" uniqKey="Yang X" first="Xing-Lou" last="Yang">Xing-Lou Yang</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mani, Shailendra" sort="Mani, Shailendra" uniqKey="Mani S" first="Shailendra" last="Mani">Shailendra Mani</name><affiliation wicri:level="1"><nlm:aff id="AF7"><institution>Programme in Emerging Infectious Diseases Duke-NUS Medical School</institution>, Singapore,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ngeiywa, Kisa Juma" sort="Ngeiywa, Kisa Juma" uniqKey="Ngeiywa K" first="Kisa-Juma" last="Ngeiywa">Kisa-Juma Ngeiywa</name><affiliation wicri:level="1"><nlm:aff id="AF5"><institution>Directorate of Veterinary Services, State Department of Livestock, Ministry of Agriculture</institution>, Livestock and Fisheries,<country>Kenya</country></nlm:aff><country xml:lang="fr">Kenya</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF6"><institution>Kenya Camel Association</institution>, Nairobi,<country>Kenya</country></nlm:aff><country xml:lang="fr">Kenya</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhu, Yan" sort="Zhu, Yan" uniqKey="Zhu Y" first="Yan" last="Zhu">Yan Zhu</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Ben" sort="Hu, Ben" uniqKey="Hu B" first="Ben" last="Hu">Ben Hu</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Onyuok, Samson Omondi" sort="Onyuok, Samson Omondi" uniqKey="Onyuok S" first="Samson Omondi" last="Onyuok">Samson Omondi Onyuok</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yan, Bing" sort="Yan, Bing" uniqKey="Yan B" first="Bing" last="Yan">Bing Yan</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Anderson, Danielle E" sort="Anderson, Danielle E" uniqKey="Anderson D" first="Danielle E." last="Anderson">Danielle E. Anderson</name><affiliation wicri:level="1"><nlm:aff id="AF7"><institution>Programme in Emerging Infectious Diseases Duke-NUS Medical School</institution>, Singapore,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name><affiliation wicri:level="1"><nlm:aff id="AF7"><institution>Programme in Emerging Infectious Diseases Duke-NUS Medical School</institution>, Singapore,<country>Singapore</country></nlm:aff><country xml:lang="fr">Singapour</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Zheng Li" sort="Shi, Zheng Li" uniqKey="Shi Z" first="Zheng-Li" last="Shi">Zheng-Li Shi</name><affiliation wicri:level="1"><nlm:aff id="AF1"><institution>CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences</institution>, Wuhan,<country>People's Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Emerging Microbes & Infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Camelus (blood)</term><term>Camelus (virology)</term><term>Chiroptera (virology)</term><term>Coronavirus (genetics)</term><term>Coronavirus (immunology)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (veterinary)</term><term>Coronavirus Infections (virology)</term><term>Kenya</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Nucleocapsid Proteins (immunology)</term><term>Recombination, Genetic</term><term>Spike Glycoprotein, Coronavirus (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Chameaux (sang)</term><term>Chameaux (virologie)</term><term>Chiroptera (virologie)</term><term>Coronavirus (génétique)</term><term>Coronavirus (immunologie)</term><term>Coronavirus (isolement et purification)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Infections à coronavirus (médecine vétérinaire)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (virologie)</term><term>Kenya</term><term>Protéines nucléocapside (immunologie)</term><term>Recombinaison génétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Nucleocapsid Proteins</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Kenya</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Camelus</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Glycoprotéine de spicule des coronavirus</term><term>Protéines nucléocapside</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Chameaux</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term><term>Chiroptera</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term><term>Chiroptera</term><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Recombination, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Kenya</term><term>Recombinaison génétique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Kenya</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Dromedary camels are important reservoir hosts of various coronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV) that cause human infections. CoV genomes regularly undergo recombination during infection as observed in bat SARS-related CoVs. Here we report for the first time that only a small proportion of MERS-CoV receptor-binding domain positive (RBD) of spike protein positive camel sera in Kenya were also seropositive to MERS-CoV nucleocapsid (NP). In contrast, many of them contain antibodies against bat HKU8-related (HKU8r)-CoVs. Among 584 camel samples that were positive against MERS-CoV RBD, we found only 0.48 (8.22%) samples were also positive for NP. Furthermore, we found bat HKU8r-CoV NP antibody in 73 (12.5%) of the MERS-CoV RBD positive and NP negative samples, yet found only 3 (0.43%) of the HKU8r-CoV S1 antibody in the same samples. These findings may indicate co-infection with MERS-CoV and a HKU8r-CoV in camels. It may also raise the possibility of the circulation of a recombinant coronavirus virus with the spike of MERS-CoV and the NP of a HKU8r-CoV in Kenya. We failed to find molecular evidence of an HKU8r-CoV or a putative recombinant virus. Our findings should alert other investigators to look for molecular evidence of HKU8r-CoV or recombinants.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author><author><name sortKey="Messadi, L" uniqKey="Messadi L">L Messadi</name></author><author><name sortKey="Feyisa, A" uniqKey="Feyisa A">A Feyisa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Corman, 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Anderson</name><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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